Background. Impairment of the endocrine and exocrine function of the pancreas is a common complication in patients with systemic iron overload, especially in thalassemia patients. Multiecho T2* MRI is a well-established technique for iron overload assessment but there are few reports concerning the pancreas. Aims. Our aims were to assess the feasibility and reproducibility of the MRI technique for measuring pancreatic regional and global T2* values, to establish the lower limit of normal in a large cohort of healthy subjects and to correlate the gained values with age and gender. Methods. One hundred and twenty healthy subjects (61 males, mean age 51±17 years) underwent MRI exam (1.5T) using a breath-hold multiecho T2* gradient-echo sequence. T2* measurements were performed in pancreatic head, body and tail. The global value was calculated as the mean.
Regional and Global Pancreatic T2* MRI for Iron overload assessment in a large cohort of healthy subjects: normal values and correlation with age and gender.
BORGNA, Caterina;
2010
Abstract
Background. Impairment of the endocrine and exocrine function of the pancreas is a common complication in patients with systemic iron overload, especially in thalassemia patients. Multiecho T2* MRI is a well-established technique for iron overload assessment but there are few reports concerning the pancreas. Aims. Our aims were to assess the feasibility and reproducibility of the MRI technique for measuring pancreatic regional and global T2* values, to establish the lower limit of normal in a large cohort of healthy subjects and to correlate the gained values with age and gender. Methods. One hundred and twenty healthy subjects (61 males, mean age 51±17 years) underwent MRI exam (1.5T) using a breath-hold multiecho T2* gradient-echo sequence. T2* measurements were performed in pancreatic head, body and tail. The global value was calculated as the mean.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
