The sunscreen agent, butyl methoxydibenzoylmethane (BMDBM), one of the most widely used UVA (320-400 nm) filter, undergoes degradation under sunlight exposure, which is a limiting factor on its overall performance. This study reports on the incorporation of BMDBM into solid lipid microparticles as a strategy to reduce the sunscreen photoinstability. The microparticles were produced using various lipid materials (tristearin, glyceryl behenate, stearic acid) and hydrogenated phosphatidylcholine as the surfactant. The efficacy of the lipid microparticles was evaluated after their introduction in a model cream. The light-induced decomposition of BMDBM was reduced from 33.8% to 15.8% by its incorporation into the lipid microparticles. Moreover, the encapsulation process did not alter the UVA protection provided by the sunscreen agent .
Photo-stabilization of butyl methoxydibenzoylmethane by encapsulation in lipid microparticles
SCALIA, Santo
2009
Abstract
The sunscreen agent, butyl methoxydibenzoylmethane (BMDBM), one of the most widely used UVA (320-400 nm) filter, undergoes degradation under sunlight exposure, which is a limiting factor on its overall performance. This study reports on the incorporation of BMDBM into solid lipid microparticles as a strategy to reduce the sunscreen photoinstability. The microparticles were produced using various lipid materials (tristearin, glyceryl behenate, stearic acid) and hydrogenated phosphatidylcholine as the surfactant. The efficacy of the lipid microparticles was evaluated after their introduction in a model cream. The light-induced decomposition of BMDBM was reduced from 33.8% to 15.8% by its incorporation into the lipid microparticles. Moreover, the encapsulation process did not alter the UVA protection provided by the sunscreen agent .I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
