The enormous blood supply to the kidney guarantees high oxygenation of these organs to aid in their intense metabolic activity. At the same time this functional organization poses several problems with the development of renal diseases and their evolution as acute and chronic pathologies. ROS are potentially produced at high level in the kidneys and contribute to the balance between healing and disease progression. In the present editorial authors discuss ROS in relation to autoimmune pathogenesis in renal diseases focusing their attention on the roles of ROS-dependent signalling pathways including metabolism of arachidonic acid, release of TGFbeta and activity of the protein kinases ERK-1/2 and MAPK.
ROS and kidney disease in the evolution from acute phase to chronic end stage disease: A commentary on "Oxidative signaling in renal epithelium: Critical role of cPLA2 and p38SAPK".
BERGAMINI, Carlo;
2006
Abstract
The enormous blood supply to the kidney guarantees high oxygenation of these organs to aid in their intense metabolic activity. At the same time this functional organization poses several problems with the development of renal diseases and their evolution as acute and chronic pathologies. ROS are potentially produced at high level in the kidneys and contribute to the balance between healing and disease progression. In the present editorial authors discuss ROS in relation to autoimmune pathogenesis in renal diseases focusing their attention on the roles of ROS-dependent signalling pathways including metabolism of arachidonic acid, release of TGFbeta and activity of the protein kinases ERK-1/2 and MAPK.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
