Many proteins involved in the neurodegeneration processes are potential metalloproteins. In some of them the metal binding domain is flexible or unstructured (e.g. prion proteins, β-amyloid peptide, α-synuclein) resembling oligo-peptide chains. The regular protein structure usually has a critical impact on the binding ability of metal ion to protein scaffold, while in peptides with random structures the individual binding ability of the particular amino acid residue may decide about the peptide binding to metal ion.

Modeling of the metal binding sites in proteins involved in neurodegeneration

REMELLI, Maurizio;
2012

Abstract

Many proteins involved in the neurodegeneration processes are potential metalloproteins. In some of them the metal binding domain is flexible or unstructured (e.g. prion proteins, β-amyloid peptide, α-synuclein) resembling oligo-peptide chains. The regular protein structure usually has a critical impact on the binding ability of metal ion to protein scaffold, while in peptides with random structures the individual binding ability of the particular amino acid residue may decide about the peptide binding to metal ion.
2012
9789814316019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1390225
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