The syndrome of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) is a rare condition characterized by a combination of osteo-articular and cutaneous manifestations. Hallmark of the disease is the presence of osteitic/hyperostotic lesions involving osteo-articular structures of the anterior chest wall (ACW). Emerging evidence suggests that SAPHO might be a primitive osteitis, probably related to polygenic autoinflammatory disorders. The rarity of the disease and its unknown aetio-pathogenesis make targeted therapy unavailable. In this report we describe for the first time effective treatment of SAPHO syndrome with the interleukin-1 receptor antagonist (IL-1Ra) anakinra.

Dysregulation of P2X7 receptor-inflammasome axis in SAPHO syndrome: successful treatment with anakinra

COLINA, Matteo;PIZZIRANI, Cinzia;FALZONI, Simonetta;BRUSCHI, MARCO;TROTTA, Francesco;DI VIRGILIO, Francesco
2010

Abstract

The syndrome of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) is a rare condition characterized by a combination of osteo-articular and cutaneous manifestations. Hallmark of the disease is the presence of osteitic/hyperostotic lesions involving osteo-articular structures of the anterior chest wall (ACW). Emerging evidence suggests that SAPHO might be a primitive osteitis, probably related to polygenic autoinflammatory disorders. The rarity of the disease and its unknown aetio-pathogenesis make targeted therapy unavailable. In this report we describe for the first time effective treatment of SAPHO syndrome with the interleukin-1 receptor antagonist (IL-1Ra) anakinra.
Colina, Matteo; Pizzirani, Cinzia; M., Khodeir; Falzoni, Simonetta; Bruschi, Marco; Trotta, Francesco; DI VIRGILIO, Francesco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1387876
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