The piperazine moiety is an important pharmacophore which is found in a large number of biologically active molecules. Although the syntheses of piperazine derivatives have been known for almost a century, chiral syntheses of 2-oxopiperazines have been rarely reported and still remain a daunting challenge to organic chemists. Therefore, the search of efficient routes towards these compounds with substitution at different ring positions are of crucial and particular significance in view of the profound importance of substituted piperazine ring systems in medicinal chemistry and drug discovery. This review provides a comprehensive survey of the methods available for the preparation of chiral 2-oxopiperazines.

Mastering chiral substituted 2-oxopiperazines

DE RISI, Carmela;PELA', Michela;POLLINI, Gian Piero;TRAPELLA, Claudio;ZANIRATO, Vinicio
2010

Abstract

The piperazine moiety is an important pharmacophore which is found in a large number of biologically active molecules. Although the syntheses of piperazine derivatives have been known for almost a century, chiral syntheses of 2-oxopiperazines have been rarely reported and still remain a daunting challenge to organic chemists. Therefore, the search of efficient routes towards these compounds with substitution at different ring positions are of crucial and particular significance in view of the profound importance of substituted piperazine ring systems in medicinal chemistry and drug discovery. This review provides a comprehensive survey of the methods available for the preparation of chiral 2-oxopiperazines.
2010
DE RISI, Carmela; Pela', Michela; Pollini, Gian Piero; Trapella, Claudio; Zanirato, Vinicio
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1386875
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 34
  • ???jsp.display-item.citation.isi??? 33
social impact