The cAMP-dependent signalling accounts for the control of cellular cascades involved in many physiological functions, and a wealth of information is available on the cAMP system that operates in mammalian cells. Nevertheless, cAMP has a central role also in non mammalian vertebrates and invertebrates. The present review aims at examining the information available on bivalve molluscs, from the first studies carried out in the early 1980s to the last progresses made in the present days. The major focus is on the structural and operational characteristics of the main actors of the signalling pathway, i.e. adenylyl cyclase, G proteins and protein kinase A, and on the role played by the cyclic nucleotide on smooth muscle, heart, gills, gonads and metabolism regulation. Moreover, recent evidence regarding the cAMP system as a target of environmental stress factors are discussed.
Cyclic AMP signalling in bivalve molluscs: an overview.
CAPUZZO, Antonio
2010
Abstract
The cAMP-dependent signalling accounts for the control of cellular cascades involved in many physiological functions, and a wealth of information is available on the cAMP system that operates in mammalian cells. Nevertheless, cAMP has a central role also in non mammalian vertebrates and invertebrates. The present review aims at examining the information available on bivalve molluscs, from the first studies carried out in the early 1980s to the last progresses made in the present days. The major focus is on the structural and operational characteristics of the main actors of the signalling pathway, i.e. adenylyl cyclase, G proteins and protein kinase A, and on the role played by the cyclic nucleotide on smooth muscle, heart, gills, gonads and metabolism regulation. Moreover, recent evidence regarding the cAMP system as a target of environmental stress factors are discussed.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
