Resting muscle VO2 consumption (rmVO2) as measured by near-infrared spectroscopy (NIRS) has been poorly studied in peripheral arterial disease (PAD). We studied the feasibility of its assessment in a clinical setting, compared values from PAD and healthy subjects, and identified factors affecting rmVO2 in PAD. 119 consecutive PAD patients with claudication and 30 healthy subjects were enrolled. Ankle-brachial index (ABI), adipose tissue thickness, and rmVO2 in the gastrocnemius after venous (rmVO2ven) or arterial (rmVO2art) occlusion were measured with NIRS. Compared to rmVO2art, rmVO2ven determination was less painful (p=0.001) and better tolerated (p=0.016), with higher values (p<0.0001). rmVO2ven of PAD patients was not significantly different from healthy subjects and was inversely correlated with the corresponding ABI (p=0.018). rmVO2ven values from severely diseased legs were higher than values from borderline or moderately diseased legs (p=0.003). The determination of rmVO2ven by NIRS is suitable for the clinical setting and allows non-invasive quantification of a compensatory peripheral adaptation in PAD patients.

Resting muscle oxygen consumption by Near-Infrared Spectroscopy in peripheral arterial disease: a parameter to be considered in a clinical setting?

Mandini S;MANFREDINI, Roberto;BASAGLIA, Nino;ZAMBONI, Paolo;MANFREDINI, Fabio
2010

Abstract

Resting muscle VO2 consumption (rmVO2) as measured by near-infrared spectroscopy (NIRS) has been poorly studied in peripheral arterial disease (PAD). We studied the feasibility of its assessment in a clinical setting, compared values from PAD and healthy subjects, and identified factors affecting rmVO2 in PAD. 119 consecutive PAD patients with claudication and 30 healthy subjects were enrolled. Ankle-brachial index (ABI), adipose tissue thickness, and rmVO2 in the gastrocnemius after venous (rmVO2ven) or arterial (rmVO2art) occlusion were measured with NIRS. Compared to rmVO2art, rmVO2ven determination was less painful (p=0.001) and better tolerated (p=0.016), with higher values (p<0.0001). rmVO2ven of PAD patients was not significantly different from healthy subjects and was inversely correlated with the corresponding ABI (p=0.018). rmVO2ven values from severely diseased legs were higher than values from borderline or moderately diseased legs (p=0.003). The determination of rmVO2ven by NIRS is suitable for the clinical setting and allows non-invasive quantification of a compensatory peripheral adaptation in PAD patients.
Malagoni, Am; Felisatti, M; Mandini, S; Mascoli, F; Manfredini, Roberto; Basaglia, Nino; Zamboni, Paolo; Manfredini, Fabio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/1381857
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