As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.
Carnitine Conjugate of Nipecotic acid: A new example of dual prodrug
NAPOLITANO, CarmelaPrimo
;SCAGLIANTI, Martina;SCALAMBRA, Emanuela;MANFREDINI, Stefano
;FERRARO, Luca Nicola;BEGGIATO, SarahPenultimo
;VERTUANI, SilviaUltimo
2009
Abstract
As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.File in questo prodotto:
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