The prediction of percutaneous absorption by means of in vitro methodologies requires good in vitro-in vivo correlation. Moreover , due to differences in the type of vehicle and in the physicochemical properties of the substances, the selection of an appropriate in vitro conditions is crucial. This chapter focuses on comparative in vitro-in vivo skin permeation of butyl methoxydibenzoylmethane, a high lipophilic UV-A absorber, methylbenzylidene camphor, a less lipophilic sunscreen agent and glycolic acid, an hydrophilic active substance.
Comparative in vitro-in vivo skin permeation of cosmetic ingredients
SCALIA, Santo
2009
Abstract
The prediction of percutaneous absorption by means of in vitro methodologies requires good in vitro-in vivo correlation. Moreover , due to differences in the type of vehicle and in the physicochemical properties of the substances, the selection of an appropriate in vitro conditions is crucial. This chapter focuses on comparative in vitro-in vivo skin permeation of butyl methoxydibenzoylmethane, a high lipophilic UV-A absorber, methylbenzylidene camphor, a less lipophilic sunscreen agent and glycolic acid, an hydrophilic active substance.File in questo prodotto:
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