HLA-G antigens are thought to play a key role in implantation by controlling trophoblasts invasion and maintaining a local immunosuppressive state. The secretion of soluble HLA-G antigens (sHLA-G) by early embryos seems necessary for a successful implantation and could be a marker of increased pregnancy rate following in vitro fertilization. We have reviewed the results obtained during the last years. They overall confirmed the predictive role of sHLA-G production in pregnancy outcome. Furthermore, we have examined the technical procedures utilized with a particular attention to the monoclonal antibodies employed in the ELISA techniques. New functional roles for HLA-G molecules in pregnancy could be suggested by the relationship observed between the presence of sHLA-G antigens in follicular fluids and sHLA-G expression in the corresponding fertilized oocyte. Furthermore, since maternal mRNA is fundamental for proteins production in early embryos, the biological role of the HLA-G 14bp polymorphism could be explored.

HLA-G expression is a fundamental prerequisite to pregnancy

RIZZO, Roberta
Primo
;
STIGNANI, Marina
Penultimo
;
BARICORDI, Olavio
Ultimo
2007

Abstract

HLA-G antigens are thought to play a key role in implantation by controlling trophoblasts invasion and maintaining a local immunosuppressive state. The secretion of soluble HLA-G antigens (sHLA-G) by early embryos seems necessary for a successful implantation and could be a marker of increased pregnancy rate following in vitro fertilization. We have reviewed the results obtained during the last years. They overall confirmed the predictive role of sHLA-G production in pregnancy outcome. Furthermore, we have examined the technical procedures utilized with a particular attention to the monoclonal antibodies employed in the ELISA techniques. New functional roles for HLA-G molecules in pregnancy could be suggested by the relationship observed between the presence of sHLA-G antigens in follicular fluids and sHLA-G expression in the corresponding fertilized oocyte. Furthermore, since maternal mRNA is fundamental for proteins production in early embryos, the biological role of the HLA-G 14bp polymorphism could be explored.
2007
Rizzo, Roberta; Melchiorri, L.; Stignani, Marina; Baricordi, Olavio
File in questo prodotto:
File Dimensione Formato  
Human Immunology_2007 Review.pdf

solo gestori archivio

Descrizione: Full text editoriale
Tipologia: Full text (versione editoriale)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 245.89 kB
Formato Adobe PDF
245.89 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1378329
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 56
  • ???jsp.display-item.citation.isi??? 50
social impact