Azole-derived antifungal agents have been studied in depth and successfully used in medicine (Kelly and Kelly, 1993). In recent years, the research and synthesis of azole-based antifungal agents have been focusing more selectively on the triazole family of substances, including fluconazole, itraconazole and terconazole. Indeed, the advantage of these compounds is their low hepatic toxicity and the fact that they have a less harmful effect on sterol synthesis in man (Saag and Dismukes, 1988) than, for example, the better known imidazole derivatives (Srivastava et al. 1991). With the aim of finding new, more active antifungal agents, the present investigation has evaluated in vitro the antifungal activity of six newly synthesized triazoles (Table 1) versus the fungal pathogen Nannizzia cajetani.
Antifungal activity of six newly synthesized triazoles
SACCHETTI, Gianni;VICENTINI, Chiara Beatrice;MARES, Donatella
1998
Abstract
Azole-derived antifungal agents have been studied in depth and successfully used in medicine (Kelly and Kelly, 1993). In recent years, the research and synthesis of azole-based antifungal agents have been focusing more selectively on the triazole family of substances, including fluconazole, itraconazole and terconazole. Indeed, the advantage of these compounds is their low hepatic toxicity and the fact that they have a less harmful effect on sterol synthesis in man (Saag and Dismukes, 1988) than, for example, the better known imidazole derivatives (Srivastava et al. 1991). With the aim of finding new, more active antifungal agents, the present investigation has evaluated in vitro the antifungal activity of six newly synthesized triazoles (Table 1) versus the fungal pathogen Nannizzia cajetani.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
