We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolated tested. Killing experiments showed that fungicidal activity was achieved after 8 h of treatment with G8 at concentration ≥ 10 mg/L. In a murine model of systemic cryptococcosis, G8 was effective at prolonging survival compared with the controls. Our data indicate that this new derivative has a potential therapeutic role in infections caused by C.neoformans.
In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative
VICENTINI, Chiara Beatrice
2003
Abstract
We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolated tested. Killing experiments showed that fungicidal activity was achieved after 8 h of treatment with G8 at concentration ≥ 10 mg/L. In a murine model of systemic cryptococcosis, G8 was effective at prolonging survival compared with the controls. Our data indicate that this new derivative has a potential therapeutic role in infections caused by C.neoformans.File in questo prodotto:
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