Episomal simian virus 40 (SV40) DNA was detected in various SV40-immortalized human fibroblast cell lines, without rearrangements or mutations. In these cells, SV40 established a persistent infection with the release of a viral progeny. However, electron microscopy analysis showed that virions are morphologically altered, whereas infectivity assay indicated that viral production was hampered. The data suggest that in SV40-infected human fibroblasts, some cells support a complete SV40 productive cycle, whereas other cells resist to the SV40 infection. This sort of "balance" observed within the same human fibroblast population may be responsible for the semipermissiveness of these cells to SV40 infection.

Simian virus 40 persistent infection in long term immortalized human fibroblast cell line

MORELLI, Cristina;IACCHERI, LAURA;TOGNON, Mauro
2004

Abstract

Episomal simian virus 40 (SV40) DNA was detected in various SV40-immortalized human fibroblast cell lines, without rearrangements or mutations. In these cells, SV40 established a persistent infection with the release of a viral progeny. However, electron microscopy analysis showed that virions are morphologically altered, whereas infectivity assay indicated that viral production was hampered. The data suggest that in SV40-infected human fibroblasts, some cells support a complete SV40 productive cycle, whereas other cells resist to the SV40 infection. This sort of "balance" observed within the same human fibroblast population may be responsible for the semipermissiveness of these cells to SV40 infection.
2004
Morelli, Cristina; Barbisan, F.; Iaccheri, Laura; Tognon, Mauro
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1209838
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
social impact