Synthesis of 6-(hydroxyphenyl)imidazo[2,1-b]thiazoles related to levamisole from the corresponding methoxy derivatives is reported. These compounds were tested on in vitro neutrophil activation namely locomotion induced by chemoattractants, superoxide generation and lysozyme degranulation triggered by agonists. These functions were evaluated after cell pulse with different concentrations of the drugs. Several derivatives showed inhibitory effects and in some cases were more potent than the parent compound.
6-(hydroxyphenyl)imidazo[2,1-b]thiazoles as potential antiinflammatory agents: Effects on human neutrophil functions
TRANIELLO, Maria Serena;CARIANI, Alessio;SPISANI, Susanna
2000
Abstract
Synthesis of 6-(hydroxyphenyl)imidazo[2,1-b]thiazoles related to levamisole from the corresponding methoxy derivatives is reported. These compounds were tested on in vitro neutrophil activation namely locomotion induced by chemoattractants, superoxide generation and lysozyme degranulation triggered by agonists. These functions were evaluated after cell pulse with different concentrations of the drugs. Several derivatives showed inhibitory effects and in some cases were more potent than the parent compound.File in questo prodotto:
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