Tetramethylguanidine-catalyzed addition of dialkyl phosphites to a,b-unsaturated carbonyl compounds, alkenenitriles, aldehydes and ketones constitutes a practical route to a variety of phosphonate synthons. The very mild conditions employed, together with the short reaction times, make the procedure highly versatile and tolerant to a range of functionalities. The proposed methodology is also convenient for the preparation of a-aminophosphonates.
Tetramethylguanidine (TMG)-catalyzed addition of dialkyl phosphites to alpha,beta-unsaturated carbonyl compounds, alkenenitriles, aldehydes, ketones and imines
SIMONI, Daniele;LAMPRONTI, Ilaria;RONDANIN, Riccardo;POLLINI, Gian Piero
1998
Abstract
Tetramethylguanidine-catalyzed addition of dialkyl phosphites to a,b-unsaturated carbonyl compounds, alkenenitriles, aldehydes and ketones constitutes a practical route to a variety of phosphonate synthons. The very mild conditions employed, together with the short reaction times, make the procedure highly versatile and tolerant to a range of functionalities. The proposed methodology is also convenient for the preparation of a-aminophosphonates.File in questo prodotto:
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