The interaction between the hydrophobic indolinolic nitroxide radical and hydrophilic cyclodextrin derivatives was investigated in water by phase-solubility analysis. Among the studied cyclodextrins methyl-beta-cyclodextrin had the greatest solubilizing activity. Photodegradation of the nitroxide was reduced by complexation with methyl-beta-cyclodextrin . The antioxidant activity of the complex was also investigated. The free form of the nitroxide as well as its complex with methyl-beta-cyclodextrin showed the same degre of protection. Moreover EPR experiments showed a time-dependent decrease in teh EPR signal of both the complex and uncomplexed nitroxide with the fre-radical generator.
Effect of complexation with randomly methylated beta-cyclodextrin on the aqueous solubility, photostability and antioxidant activity of an indolinonic nitroxide radical
SCALIA, Santo
2005
Abstract
The interaction between the hydrophobic indolinolic nitroxide radical and hydrophilic cyclodextrin derivatives was investigated in water by phase-solubility analysis. Among the studied cyclodextrins methyl-beta-cyclodextrin had the greatest solubilizing activity. Photodegradation of the nitroxide was reduced by complexation with methyl-beta-cyclodextrin . The antioxidant activity of the complex was also investigated. The free form of the nitroxide as well as its complex with methyl-beta-cyclodextrin showed the same degre of protection. Moreover EPR experiments showed a time-dependent decrease in teh EPR signal of both the complex and uncomplexed nitroxide with the fre-radical generator.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.