The interaction between oxybenzone and hydrophilic cyclodextrin derivatives was studied in water by phase solubility analysis. Among the available cyclodextrins, sulfobutyl-beta-cyclodextrin had the greatest solubilizing activity. Ethanol-water solution containing oxybenzone free or complexed with cyclodextrin were applied to human skin in Franz diffusion cells and the amount of sunscreen permeated into the different cutaneous comaprtements was determined by HPLC.The sunscreen penetration to the deeper living layers of the skin was remarkebly lower upon application of the sunscreen complexed with sulfobutyl-beta-cyclodextrin .
Influence of cyclodextrin complexation on the in vitro human skin penetration and retention of the sunscreen agent, oxybenzone
SCALIA, Santo;
2006
Abstract
The interaction between oxybenzone and hydrophilic cyclodextrin derivatives was studied in water by phase solubility analysis. Among the available cyclodextrins, sulfobutyl-beta-cyclodextrin had the greatest solubilizing activity. Ethanol-water solution containing oxybenzone free or complexed with cyclodextrin were applied to human skin in Franz diffusion cells and the amount of sunscreen permeated into the different cutaneous comaprtements was determined by HPLC.The sunscreen penetration to the deeper living layers of the skin was remarkebly lower upon application of the sunscreen complexed with sulfobutyl-beta-cyclodextrin .File in questo prodotto:
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