Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2α-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity.
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Data di pubblicazione: | 2005 | |
Titolo: | Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines | |
Autori: | POLI F.; APPENDINO G.; SACCHETTI G.; BALLERO M.; MAGGIANO N.; RANELLETTI F.O. | |
Rivista: | PHYTOTHERAPY RESEARCH | |
Parole Chiave: | Ferula communis; Ferula arrigonii; daucane esters; antiproliferative effects; binding to Type II EBS | |
Abstract: | Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2α-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity. | |
Digital Object Identifier (DOI): | 10.1002/ptr.1443 | |
Handle: | http://hdl.handle.net/11392/1208653 | |
Appare nelle tipologie: | 03.1 Articolo su rivista |