The purpose of these controlled clinical trials was to evaluate the effect of a fibrin-fibronectin sealing system (FFSS) application on periodontal wound healing. Treatment outcomes following periodontal surgery were investigated by selecting different surgical procedures where wound stability was affected by defect anatomy, surface treatment, flap management and adjunctive application of wound-stabilising devices. In each patient, treatment modalities were randomly assigned according to a split-mouth design. In the first trial, 11 patients presenting with a pair of moderate to severe supra-alveolar defects were treated with flap debridement surgery with or without tetracycline HCl (TTC) root conditioning and FFSS application. In the second trial, 11 patients presenting with a pair of buccal gingival recession defects were treated with coronally positioned flap procedure and TTC root conditioning with and without FFSS application. In the third trial, 8 patients presenting with a pair of buccal gingival recession defects were treated with coronally positioned flap procedure, TTC root conditioning and teflon membrane with and without FFSS application. Conventional probing recordings, including probing depth, clinical attachment level and recession depth, were made immediately before surgery and 6 months postsurgery. Overall, the results indicated that periodontal healing following surgery resulted in a clinically and statistically significant improvement in the defect, and that the adjunctive application of FFSS produced limited to no enhancement of treatment outcome.
Effect of topical application of a fibrin-fibronectin sealing system on healing response following periodontal surgical procedures
TROMBELLI, Leonardo;SCABBIA, Alessandro;CALURA, Giorgio
1997
Abstract
The purpose of these controlled clinical trials was to evaluate the effect of a fibrin-fibronectin sealing system (FFSS) application on periodontal wound healing. Treatment outcomes following periodontal surgery were investigated by selecting different surgical procedures where wound stability was affected by defect anatomy, surface treatment, flap management and adjunctive application of wound-stabilising devices. In each patient, treatment modalities were randomly assigned according to a split-mouth design. In the first trial, 11 patients presenting with a pair of moderate to severe supra-alveolar defects were treated with flap debridement surgery with or without tetracycline HCl (TTC) root conditioning and FFSS application. In the second trial, 11 patients presenting with a pair of buccal gingival recession defects were treated with coronally positioned flap procedure and TTC root conditioning with and without FFSS application. In the third trial, 8 patients presenting with a pair of buccal gingival recession defects were treated with coronally positioned flap procedure, TTC root conditioning and teflon membrane with and without FFSS application. Conventional probing recordings, including probing depth, clinical attachment level and recession depth, were made immediately before surgery and 6 months postsurgery. Overall, the results indicated that periodontal healing following surgery resulted in a clinically and statistically significant improvement in the defect, and that the adjunctive application of FFSS produced limited to no enhancement of treatment outcome.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
