Various methodological approaches that can be used to detect ototoxic effects caused by the administration of various substances are presented, using the Sprague-Dawley rat as an animal model. Electrophysiological data are also presented to show how the model behaves with potentially ototoxic (hyaluronic acid) and initially inert (hydroxy-propyl-methyl-cellulose) substances.

An Animal Model Based on the Sprague Dawley rat for the Evaluation of Ototoxicity

MARTINI, Alessandro;HATZOPOULOS, Stavros;
1999

Abstract

Various methodological approaches that can be used to detect ototoxic effects caused by the administration of various substances are presented, using the Sprague-Dawley rat as an animal model. Electrophysiological data are also presented to show how the model behaves with potentially ototoxic (hyaluronic acid) and initially inert (hydroxy-propyl-methyl-cellulose) substances.
Martini, Alessandro; Hatzopoulos, Stavros; Rubini, R; DI STEFANO, M; Albertin, A; Govoni, E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1205850
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