A series of secondary and tertiary pyridyl amides as potential central nicotinic acetylcholine receptors (nAChRs) ligands were prepared. Amides displayed negligible or very low affinity, whereas two amines achieved by reduction of corresponding secondary amides, showed affinity in the nanomolar range for nAChRs.

Synthesis and binding of 3-aminopyridine derivatives at central nicotinic receptors

MARASTONI, Mauro;MERIGHI, Stefania;
2000

Abstract

A series of secondary and tertiary pyridyl amides as potential central nicotinic acetylcholine receptors (nAChRs) ligands were prepared. Amides displayed negligible or very low affinity, whereas two amines achieved by reduction of corresponding secondary amides, showed affinity in the nanomolar range for nAChRs.
Balboni, G; Marastoni, Mauro; Merighi, Stefania; Borea, Pa; Tomatis, R.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/1205797
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