Reactions of 2-bromopropanamides with potassium enolates of representative beta dicarbonyl compounds provide, in high yields, open and heterocyclic compounds through a C-C or C-O akylation reaction. Whereas C-alkylation products form in all conditions tested under relevant diastereoselectivity, O-alkylation takes place only in the presence of silver promoters, and shows partial diastereoselectivity.
Reactions of 2-bromopropanamides with conjugated bases of representative beta-dicarbonyl compounds. Synthesis of 2,5-dioxopyrrolidines and oxazolidine-4-ones
MARCHETTI, Paolo
2003
Abstract
Reactions of 2-bromopropanamides with potassium enolates of representative beta dicarbonyl compounds provide, in high yields, open and heterocyclic compounds through a C-C or C-O akylation reaction. Whereas C-alkylation products form in all conditions tested under relevant diastereoselectivity, O-alkylation takes place only in the presence of silver promoters, and shows partial diastereoselectivity.File in questo prodotto:
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