Synthetic pathways to a mononucleotide prodrug of cytarabine (Ara-C) bearing S-pivaloyl-2-thioethyl (tBuSATE) groups, as biolabile phosphate protections, are reported. Using a common phosphoramidite approach, two different kinds of nucleoside protecting groups have been investigated. During this study, we obsd. an intermol. migration of the Boc protecting group in the course of the tert-butyldimethylsilyl ether cleavage using tetra-Bu ammonium fluoride

Synthetic approaches to a mononucleotide prodrug of cytarabine

MANFREDINI, Stefano
Ultimo
2005

Abstract

Synthetic pathways to a mononucleotide prodrug of cytarabine (Ara-C) bearing S-pivaloyl-2-thioethyl (tBuSATE) groups, as biolabile phosphate protections, are reported. Using a common phosphoramidite approach, two different kinds of nucleoside protecting groups have been investigated. During this study, we obsd. an intermol. migration of the Boc protecting group in the course of the tert-butyldimethylsilyl ether cleavage using tetra-Bu ammonium fluoride
2005
Bazzanini, R.; Gouy, M. H.; Peyrottes, S.; Gosselin, G.; Perigaud, C.; Manfredini, Stefano
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1205274
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