The antifungal antibiotic, polyoxin J 1, has been obtained (46.4%) by the coupling of a protected derivative of 5-O-carbamoylpolyoxamic acid 2 with thymine polyoxin C 3 which were prepared by a stereoselective aminohomologation strategy of sugar aldehydes (L-threose and dialdo-D-ribofuranose) employing nitrones 4 and 5 as their iminium derivatives and furan as a carboxylate group equivalent.
Total synthesis of (+)-polyoxin J
DONDONI, Alessandro;
1995
Abstract
The antifungal antibiotic, polyoxin J 1, has been obtained (46.4%) by the coupling of a protected derivative of 5-O-carbamoylpolyoxamic acid 2 with thymine polyoxin C 3 which were prepared by a stereoselective aminohomologation strategy of sugar aldehydes (L-threose and dialdo-D-ribofuranose) employing nitrones 4 and 5 as their iminium derivatives and furan as a carboxylate group equivalent.File in questo prodotto:
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