The addition reaction of diethyl phosphite to O-silylated N-benzyl nitrones derived from chiral alpha-alkoxy and N-Boc alpha-amino aldehydes has been studied as a stereoselective carbon-phosphorus bond forming process for the synthesis of polyhydroxylated alpha-amino and alpha,beta-diamino phosphonates. Key intermediates are the corresponding N-hydroxy alpha-amino phosphonates.

O-Silyl triflate-promoted addition of diethyl phosphite to chiral aldonitrones. A rapid access to complex alpha-amino phosphonates and their N-hydroxy derivatives

DE RISI, Carmela;DONDONI, Alessandro;PERRONE, Daniela;POLLINI, Gian Piero
2001

Abstract

The addition reaction of diethyl phosphite to O-silylated N-benzyl nitrones derived from chiral alpha-alkoxy and N-Boc alpha-amino aldehydes has been studied as a stereoselective carbon-phosphorus bond forming process for the synthesis of polyhydroxylated alpha-amino and alpha,beta-diamino phosphonates. Key intermediates are the corresponding N-hydroxy alpha-amino phosphonates.
DE RISI, Carmela; Dondoni, Alessandro; Perrone, Daniela; Pollini, Gian Piero
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1201424
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 23
social impact