A new approach to a solution-phase oligosaccharide synthesis using an excess of glycosyl acceptor and removal of the unreacted residue by an orchestrated sequence of very efficient steps employing trichloroacetyl isocyanate as sequestering enabling reagent (SER) is described. It is also illustrated the hybrid solution/solid-phase synthesis of oligosaccharide products based on the use of the levulinoyl ester group as masked tag in a ”resin-capture-release” purification strategy.
Hybrid solution/solid-phase synthesis of oligosaccharides by using trichloroacetyl isocyanate as sequestration-enabling reagent of sugar alcohols
DONDONI, Alessandro;MARRA, Alberto;MASSI, Alessandro
2005
Abstract
A new approach to a solution-phase oligosaccharide synthesis using an excess of glycosyl acceptor and removal of the unreacted residue by an orchestrated sequence of very efficient steps employing trichloroacetyl isocyanate as sequestering enabling reagent (SER) is described. It is also illustrated the hybrid solution/solid-phase synthesis of oligosaccharide products based on the use of the levulinoyl ester group as masked tag in a ”resin-capture-release” purification strategy.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
