The aim of the present paper was to find a "biocompatible" means to cross-link gelatin based pharmaceutical devices. In particular, we have studied the ability of native and oxidized mono- and di-saccharides to induce the cross-linking of gelatin. To this end gelatin discs and gelatin microspheres were produced and their dissolution kinetics at 37°C were examined. In order to find evidence of sugar mediated cross-linking, DSC and FTIR experiments were performed. The obtained results indicated that both native and oxidized sugars resulted to different extents, in the formation of a cross-linked gelatin network able to reduce the dissolution of gelatin. These results suggest that oxidized mono- and disaccharides could be an interesting method by which to cross-link gelatin thereby reducing the risk of toxic side effects arising from the use of synthetic cross-linkers.
Sugar cross-linked gelatin for controlled release: microspheres and disks
CORTESI, Rita;NASTRUZZI, Claudio;
1998
Abstract
The aim of the present paper was to find a "biocompatible" means to cross-link gelatin based pharmaceutical devices. In particular, we have studied the ability of native and oxidized mono- and di-saccharides to induce the cross-linking of gelatin. To this end gelatin discs and gelatin microspheres were produced and their dissolution kinetics at 37°C were examined. In order to find evidence of sugar mediated cross-linking, DSC and FTIR experiments were performed. The obtained results indicated that both native and oxidized sugars resulted to different extents, in the formation of a cross-linked gelatin network able to reduce the dissolution of gelatin. These results suggest that oxidized mono- and disaccharides could be an interesting method by which to cross-link gelatin thereby reducing the risk of toxic side effects arising from the use of synthetic cross-linkers.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
