beta-Enaminoketoesters, obtained by metal-catalyzed reaction between alkyl acetoacetates and alkyl cyanoformates, are useful starting materials for rapid access to beta-acetyl-dehydroaspartic acid derivatives which could be transformed into (+/-)-2-azetidinones bearing a 1-hydroxy-ethyl substituent through suitable reductive processes.
A new simple route for the synthesis of (+/-)-2-azetidinones starting from beta-enaminoketoesters
DE RISI, Carmela;POLLINI, Gian Piero;VERONESE, Augusto;BERTOLASI, Valerio
1999
Abstract
beta-Enaminoketoesters, obtained by metal-catalyzed reaction between alkyl acetoacetates and alkyl cyanoformates, are useful starting materials for rapid access to beta-acetyl-dehydroaspartic acid derivatives which could be transformed into (+/-)-2-azetidinones bearing a 1-hydroxy-ethyl substituent through suitable reductive processes.File in questo prodotto:
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