Reduction of β-phthalimido-α-keto phosphonates, obtained through an Arbuzov reaction between the appropriate acid chloride and triethyl phosphite, with boranes and oxazaborolidine as catalyst, afforded β-phthalimido-α-hydroxy phosphonates in good yields and high diastereoselectivity. Deprotection of the amino group gave the title compounds.

Diastereoselective synthesis of beta-amino-alpha-hydroxy phosphonates via oxazaborolidine catalyzed reduction of beta-phthalimido-alpha-keto phosphonates

BARCO, Achille;BENETTI, Simonetta;BERGAMINI, Paola;DE RISI, Carmela;MARCHETTI, Paolo;POLLINI, Gian Piero;ZANIRATO, Vinicio
1999

Abstract

Reduction of β-phthalimido-α-keto phosphonates, obtained through an Arbuzov reaction between the appropriate acid chloride and triethyl phosphite, with boranes and oxazaborolidine as catalyst, afforded β-phthalimido-α-hydroxy phosphonates in good yields and high diastereoselectivity. Deprotection of the amino group gave the title compounds.
1999
Barco, Achille; Benetti, Simonetta; Bergamini, Paola; DE RISI, Carmela; Marchetti, Paolo; Pollini, Gian Piero; Zanirato, Vinicio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1197410
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