Complexes [Pt(μ-N,S-8-TT)(PPh3)2]2 (1), [Pt(μ-S,N-8-TT)(PTA)2]2 (2), [Pt(8-TTH)(terpy)]BF 4 (3), cis-[PtCl(8-MTT)(PPh3)2] (4), cis-[Pt(8-MTT)2(PPh3)2] (5), cis-[Pt(8-MTT)(8-TTH)(PPh3)2] (6), cis-[PtCl(8-MTT)(PTA)2] (7), cis-[Pt(8-MTT)2(PTA) 2] (8), and trans-[Pt(8-MTT)2(py)2] (9) (8-TTH2 = 8-thiotheophylline; 8-MTTH: = 8-(methylthio)theophylline; PTA = 1,3,5-triaza-7-phosphaadamantane) are presented and studied by IR and multinuclear (1H, 31P{1H}) NMR spectroscopy. The solid-state structure of 4 and 9 has been authenticated by X-ray crystallography. Growth inhibition of the cancer cells T2 and SKOV3 induced by the above new thiopurine platinum complexes has been investigated. The activity shown by complexes 4 and 9 was comparable with cisplatin on T2. Remarkably, 4 and 9 displayed also a valuable activity on cisplatin-resistant SKOV3 cancer cells.
Biologically active platinum complexes containing 8-thiotheophylline and 8-(methylthio)theophylline
BERGAMINI, Paola;BERTOLASI, Valerio;CANELLA, Alessandro;CATTABRIGA, Michela;GAVIOLI, Riccardo;
2004
Abstract
Complexes [Pt(μ-N,S-8-TT)(PPh3)2]2 (1), [Pt(μ-S,N-8-TT)(PTA)2]2 (2), [Pt(8-TTH)(terpy)]BF 4 (3), cis-[PtCl(8-MTT)(PPh3)2] (4), cis-[Pt(8-MTT)2(PPh3)2] (5), cis-[Pt(8-MTT)(8-TTH)(PPh3)2] (6), cis-[PtCl(8-MTT)(PTA)2] (7), cis-[Pt(8-MTT)2(PTA) 2] (8), and trans-[Pt(8-MTT)2(py)2] (9) (8-TTH2 = 8-thiotheophylline; 8-MTTH: = 8-(methylthio)theophylline; PTA = 1,3,5-triaza-7-phosphaadamantane) are presented and studied by IR and multinuclear (1H, 31P{1H}) NMR spectroscopy. The solid-state structure of 4 and 9 has been authenticated by X-ray crystallography. Growth inhibition of the cancer cells T2 and SKOV3 induced by the above new thiopurine platinum complexes has been investigated. The activity shown by complexes 4 and 9 was comparable with cisplatin on T2. Remarkably, 4 and 9 displayed also a valuable activity on cisplatin-resistant SKOV3 cancer cells.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
