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EnglishThe suggested role of cAMP in the regulation of amnionic prostaglandin release was investigated using two adenylate cyclase inhibitors, MDL 12330A and SQ 22536. These substances exhibited a dose-dependent inhibitory effect on both amnionic enzyme and cAMP levels, but they did not influence prostaglandin E (PGE) release. In addition forskolin and IBMX (3-isobutyl-1-methylxanthine), two drugs known to increase cAMP levels, did not affect PGE output, while dibutyryl cyclic cAMP showed a dose-dependent inhibitory effect. On the basis of our data, the suggested role of amnionic adenylate cyclase in triggering prostaglandin release is not confirmed, and the pathway of phospholipase A 2 activation at the onset of labor remains to be elucidated.
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http://hdl.handle.net/11392/1197071| Titolo: | THE CONTROVERSIAL ROLE OF CAMP ON AMNIOTIC PROSTAGLANDIN RELEASE - EFFECT OF ADENYLATE-CYCLASE INHIBITION |
| Autori interni: | VESCE, Fortunato BIONDI, Carla FERRETTI, Maria Enrica PARESCHI, Maria Cristina BUZZI, Marco |
| Data di pubblicazione: | 1995 |
| Rivista: | GYNECOLOGIC AND OBSTETRIC INVESTIGATION |
| Abstract: | The suggested role of cAMP in the regulation of amnionic prostaglandin release was investigated using two adenylate cyclase inhibitors, MDL 12330A and SQ 22536. These substances exhibited a dose-dependent inhibitory effect on both amnionic enzyme and cAMP levels, but they did not influence prostaglandin E (PGE) release. In addition forskolin and IBMX (3-isobutyl-1-methylxanthine), two drugs known to increase cAMP levels, did not affect PGE output, while dibutyryl cyclic cAMP showed a dose-dependent inhibitory effect. On the basis of our data, the suggested role of amnionic adenylate cyclase in triggering prostaglandin release is not confirmed, and the pathway of phospholipase A 2 activation at the onset of labor remains to be elucidated. |
| Handle: | http://hdl.handle.net/11392/1197071 |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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