Brest feeding is associated with a lower incidence of allergic and infectious diseases. This effect is due in part to the stimulatory effect of the intestinal flora on the postnatal development of the immune system. Along with other components of human milk, oligosaccharides play a key role in positively influencing the postnatal development of the intestinal flora. Human milk oligosaccharides contain app. 80% neutral and 20% acidic structures. In the search for functional analogues of human milk oligosaccharides for use in infant formulas, we developed a mixture of neutral oligo-saccharides consisting of galacto-oligosaccharides (GOS) and long chain fructo-oligosaccharides (FOS). More recently, we have also investigated acidic oligosaccharides (AOS) derived from pectin hydrolysate. (...) The text deals with the clinical result obtained with GOS/FOS and with their biochemical effects on fatty acids and prostaglandin production. Thus the effects on immune system modulation are deeply exposed.
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