Purpose of review: Seasonal variations in the incidence of cardiovascular disease, mainly characterized by a winter peak, have been consistently reported. Some evidences now also exist on potential seasonal variations in the incidence of venous thromboembolism (VTE). Of interest, seasonal variability in the incidence of deep vein thrombosis (DVT) and fatal and non fatal pulmonary embolism (PE) appears to differ; however, the results of available studies are not univocal. This review will briefly summarize current evidences in this area. Recent findings: recent studies indicate a seasonal variability in the incidence of VTE, with a pattern that is independent of gender, age, type of event, or underlying risk factors. Usually, these studies found a higher VTE incidence during the winter months and a lower incidence in the summer months. The exact mechanism of this variability is not completely understood, but it may be at least in part explained by changes in coagulation factors levels. Summary: Confirmation of these findings and a better understanding of underlying mechanisms could help physicians to identify patients or periods at increased risk of VTE in order to further improve current prophylactic strategies.

Seasonal variability of venous thromboembolism

MANFREDINI, Roberto;
2009

Abstract

Purpose of review: Seasonal variations in the incidence of cardiovascular disease, mainly characterized by a winter peak, have been consistently reported. Some evidences now also exist on potential seasonal variations in the incidence of venous thromboembolism (VTE). Of interest, seasonal variability in the incidence of deep vein thrombosis (DVT) and fatal and non fatal pulmonary embolism (PE) appears to differ; however, the results of available studies are not univocal. This review will briefly summarize current evidences in this area. Recent findings: recent studies indicate a seasonal variability in the incidence of VTE, with a pattern that is independent of gender, age, type of event, or underlying risk factors. Usually, these studies found a higher VTE incidence during the winter months and a lower incidence in the summer months. The exact mechanism of this variability is not completely understood, but it may be at least in part explained by changes in coagulation factors levels. Summary: Confirmation of these findings and a better understanding of underlying mechanisms could help physicians to identify patients or periods at increased risk of VTE in order to further improve current prophylactic strategies.
Dentali, F; Manfredini, Roberto; Ageno, W.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/535250
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