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EnglishN-myc proto-oncogene rearrangement was found in three out of six AKR murine T-cell lymphomas induced by the highly oncogenic MCF 247 MuLV. Molecular analyses showed that structural modification of the proto-oncogene in all three lymphomas was in the consequence of MCF 247 proviral integration within the gene III exon. All integrated proviruses have the same transcriptional orientation as the N-myc gene. As a consequence of proviral insertion, the N-myc gene becomes transcriptionally active, producing an abnormal mRNA. These findings suggest a possible causative role of such an integrative event in murine T-cell lymphomagenesis.
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| Data di pubblicazione: | 1989 | |
| Titolo: | N-myc activation by proviral insertion in MCF 247-induced murine T-cell lymphomas. | |
| Autori: | Dolcetti R; Rizzo S; Viel A; Maestro R; De Re V; Feriotto G; Boiocchi M. | |
| Rivista: | ONCOGENE | |
| Parole Chiave: | N-myc proto-oncogene; T-cell lymphomagenesis; MCF 247 proviral integration | |
| Abstract: | N-myc proto-oncogene rearrangement was found in three out of six AKR murine T-cell lymphomas induced by the highly oncogenic MCF 247 MuLV. Molecular analyses showed that structural modification of the proto-oncogene in all three lymphomas was in the consequence of MCF 247 proviral integration within the gene III exon. All integrated proviruses have the same transcriptional orientation as the N-myc gene. As a consequence of proviral insertion, the N-myc gene becomes transcriptionally active, producing an abnormal mRNA. These findings suggest a possible causative role of such an integrative event in murine T-cell lymphomagenesis. | |
| Handle: | http://hdl.handle.net/11392/534505 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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