Hydrogen bond (H-bond) effects are known: it makes sea water liquid, joins cellulose microfibrils in trees, shapes DNA into genes and polypeptide chains into wool, hair, muscles or enzymes. Its true nature is less known and we may still wonder why O-H...O bond energies range from less than 1 to more than 30 kcal/mol without apparent reason. This H-bond puzzle is re-examined here from its very beginning on the ground of an inclusive compilation of experimental H-bond energies and geometries. New concepts emerge from this analysis: new classes of systematically strong H-bonds (CAHBs and RAHBs: charge- and resonance-assisted H-bonds); full H-bond classification in six classes (the six chemical leitmotifs); and assessment of the covalent nature of strong H-bonds. This leads to three distinct but interconsistent models able to rationalize the H-bond and predict its strength, based on classical VB theory, matching of donor-acceptor acid-base parameters (PA or pKa), or shape of the H-bond protontransfer pathway. Applications survey a number of systems where strong H-bonds play an important functional role, namely drug-receptor binding, enzymatic catalysis, ion-transport through cell membranes, crystal design and molecular mechanisms of functional materials. This book: Presents the most comprehensive H-bond interpretation in terms of classical chemical bonding theories; Combines classical thermodynamics and structural crystallography to relate H-bond energies and geometries; Analyses the relationships between H-bond enthalpies and Gibbs free energies, and discusses binding constants in gas phase, non-polar solvents, crystals, and aqueous solution; Provides detailed analysis of the functional role played by strong H-bonds in the mechanisms of important chemical and biochemical processes, such as enzymatic catalysis, transport through cell membranes, crystal design, prototropic tautomerism, and molecular mechanisms of functional materials. Readership: Researchers, lecturers, and postgraduates in crystallography, chemistry, molecular biology and pharmacology, molecular material sciences, and solid-state physics.
The Nature of the Hydrogen Bond. Outline of a Comprehensive Hydrogen Bond Theory.
GILLI, Gastone;GILLI, Paola
2009
Abstract
Hydrogen bond (H-bond) effects are known: it makes sea water liquid, joins cellulose microfibrils in trees, shapes DNA into genes and polypeptide chains into wool, hair, muscles or enzymes. Its true nature is less known and we may still wonder why O-H...O bond energies range from less than 1 to more than 30 kcal/mol without apparent reason. This H-bond puzzle is re-examined here from its very beginning on the ground of an inclusive compilation of experimental H-bond energies and geometries. New concepts emerge from this analysis: new classes of systematically strong H-bonds (CAHBs and RAHBs: charge- and resonance-assisted H-bonds); full H-bond classification in six classes (the six chemical leitmotifs); and assessment of the covalent nature of strong H-bonds. This leads to three distinct but interconsistent models able to rationalize the H-bond and predict its strength, based on classical VB theory, matching of donor-acceptor acid-base parameters (PA or pKa), or shape of the H-bond protontransfer pathway. Applications survey a number of systems where strong H-bonds play an important functional role, namely drug-receptor binding, enzymatic catalysis, ion-transport through cell membranes, crystal design and molecular mechanisms of functional materials. This book: Presents the most comprehensive H-bond interpretation in terms of classical chemical bonding theories; Combines classical thermodynamics and structural crystallography to relate H-bond energies and geometries; Analyses the relationships between H-bond enthalpies and Gibbs free energies, and discusses binding constants in gas phase, non-polar solvents, crystals, and aqueous solution; Provides detailed analysis of the functional role played by strong H-bonds in the mechanisms of important chemical and biochemical processes, such as enzymatic catalysis, transport through cell membranes, crystal design, prototropic tautomerism, and molecular mechanisms of functional materials. Readership: Researchers, lecturers, and postgraduates in crystallography, chemistry, molecular biology and pharmacology, molecular material sciences, and solid-state physics.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
