Alterations in miRNA genes and other non-coding RNAs play a critical role in the pathophysiology of all human cancers: cancer initiation and progression can involve microRNAs (miRNAs) – small non-coding RNAs that can regulate gene expression. At present, the main mechanism of microRNoma (defined as the full complement of microRNAs present in a genome) alteration in cancer cells seems to be represented by aberrant gene expression, characterized by abnormal levels of expression for mature and/or precursor miRNA sequences in comparison with the corresponding normal tissues. MicroRNAs expression profiling has been exploited to identify miRNAs that are potentially involved in the pathogenesis of human cancers. MicroRNAs and other non-coding RNAs profiling achieved by various methods has allowed the identification of signatures associated with diagnosis, staging, progression, prognosis, and response to treatment of human tumors.
Significance of Aberrant Expression of MicroRNAs in Cancer Cells
FERRACIN, Manuela;VOLINIA, Stefano;NEGRINI, Massimo;CROCE, Carlo Maria
2009
Abstract
Alterations in miRNA genes and other non-coding RNAs play a critical role in the pathophysiology of all human cancers: cancer initiation and progression can involve microRNAs (miRNAs) – small non-coding RNAs that can regulate gene expression. At present, the main mechanism of microRNoma (defined as the full complement of microRNAs present in a genome) alteration in cancer cells seems to be represented by aberrant gene expression, characterized by abnormal levels of expression for mature and/or precursor miRNA sequences in comparison with the corresponding normal tissues. MicroRNAs expression profiling has been exploited to identify miRNAs that are potentially involved in the pathogenesis of human cancers. MicroRNAs and other non-coding RNAs profiling achieved by various methods has allowed the identification of signatures associated with diagnosis, staging, progression, prognosis, and response to treatment of human tumors.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
