Non-natural axially and equatorially linked C-glycosyl alpha-amino acids (glycines, alanines, and CH2-serine isosteres) with either S or R alpha-configuration were prepared by D- and L-proline-catalyzed (de >95%) alpha-amination of C-glycosylalkyl aldehydes using dibenzyl azodicarboxylate as the electrophilic reagent.
General Synthesis of C-Glycosyl Amino Acids via Proline-Catalyzed Direct Electrophilic alpha-Amination of C-Glycosylalkyl Aldehydes
MASSI, Alessandro;DONDONI, Alessandro;NUZZI, Andrea
2008
Abstract
Non-natural axially and equatorially linked C-glycosyl alpha-amino acids (glycines, alanines, and CH2-serine isosteres) with either S or R alpha-configuration were prepared by D- and L-proline-catalyzed (de >95%) alpha-amination of C-glycosylalkyl aldehydes using dibenzyl azodicarboxylate as the electrophilic reagent.File in questo prodotto:
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