A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.

Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties

SIMONI, Daniele;RONDANIN, Riccardo;BARUCHELLO, Riccardo;RIZZI, Michele;GRISOLIA, Giuseppina;ELEOPRA, Marco;
2008

Abstract

A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.
2008
Simoni, Daniele; Rondanin, Riccardo; Baruchello, Riccardo; Rizzi, Michele; Grisolia, Giuseppina; Eleopra, Marco; Stefania, Grimaudo; Antonietta Di, Cristina; Maria Rosaria, Pipitone; Maria Rita, Bongiorno; Mario, Aricò; Francesco Paolo, Invidiata; Manlio, Tolomeo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/529728
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