Downstream A3 receptor signaling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A3 receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated protein kinase (MAPK/Erk) kinase (MEK)/mitogen-activated protein kinase (MAPK) pathways have central roles in the regulation of cell survival and proliferation. The crosstalk between these two pathways has also been also investigated. The focus of this review centers on downstream mediators of A3 adenosine receptor signalling.
MODULATION OF THE AKT/RAS/RAF/MEK/ERK PATHWAY BY A3 ADENOSINE RECEPTOR
MERIGHI, Stefania;BENINI, Annalisa;MIRANDOLA, Prisco;GESSI, Stefania;VARANI, Katia;BARALDI, Pier Giovanni;BOREA, Pier Andrea
2006
Abstract
Downstream A3 receptor signaling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A3 receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated protein kinase (MAPK/Erk) kinase (MEK)/mitogen-activated protein kinase (MAPK) pathways have central roles in the regulation of cell survival and proliferation. The crosstalk between these two pathways has also been also investigated. The focus of this review centers on downstream mediators of A3 adenosine receptor signalling.File in questo prodotto:
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