Female mice of the C3H, C3Hf and Swiss albino lines were inoculated intravaginally with subtypes 1 and 2 of Herpes simplex virus (HSV 1 and HSV 2). Both subtypes were reisolated from the vagina but death only followed HSV 2 inoculation. Virus was reisolated from the brain and not from other internal organs of intravaginally inoculated mice. Swiss mice proved more susceptible than C3H and C3Hf mice. In mice which survived the intravaginal and intracerebral inoculation of HSV 1 and HSV 2, an intramuscular inoculation of nor adrenaline was not followed by reactivation of herpetic infection. In vitro, both subtypes did bind to brain suspensions of C3Hf mice but only HSV 2 was isolated from brains of the intravaginally inoculated mice.
Intravaginal infection in mice with two subtypes of Herpes simplex virus
CASSAI, Enzo;CORALLINI, Alfredo;CANELLA, Cinzia
1973
Abstract
Female mice of the C3H, C3Hf and Swiss albino lines were inoculated intravaginally with subtypes 1 and 2 of Herpes simplex virus (HSV 1 and HSV 2). Both subtypes were reisolated from the vagina but death only followed HSV 2 inoculation. Virus was reisolated from the brain and not from other internal organs of intravaginally inoculated mice. Swiss mice proved more susceptible than C3H and C3Hf mice. In mice which survived the intravaginal and intracerebral inoculation of HSV 1 and HSV 2, an intramuscular inoculation of nor adrenaline was not followed by reactivation of herpetic infection. In vitro, both subtypes did bind to brain suspensions of C3Hf mice but only HSV 2 was isolated from brains of the intravaginally inoculated mice.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
