Aim: An ongoing multicentre, randomised, placebo-controlled study evaluating the impact of tiotropium (Spiriva) on the outcomes of rehabilitation offered the opportunity to assess the correlation of exercise endurance with lung function parameters, and patient-reported breathlessness, in 220 patients with stable COPD. Methods. Baseline parameters of patients randomised as of March 2005, were analysed for correlations of lung function parameters (Forced Expiratory Volume in one second FEV1; Forced Vital Capacity, FVC), breathlessness (Baseline Dyspnea Index, BDI) with exercise performance (Six Minute Walk Distance,6MWD). Correlations among variables were evaluated with the Spearman correlation coefficient. Results. Data from 207 COPD patients (85.5% male, [meanSD] age 678 years, age median 67 years) were available. Patients showed: FVC: 2.50 0.92 L; FEV1: 1.15 0.65 L; BDI focal score: 6.54 2.40; 6MWD: 399 120 m. SaO2: 95.5 1.7 %. The relative correlations of 6MWD to lung function parameters and patient breathlessness were: (1)with FVC : R=0.317, p< 0.0001; (2)with BDI: R = 0.227, p= 0.0011, (3)with FEV1: R=0.193, p = 0.0053. Conclusions. We conclude that in COPD patients spirometric and symptom parameters are significantly correlated with exercise tolerance. The strongest correlation of 6MWD was established to FVC, while FEV1 was more weakly correlated. Studies evaluating effects of treatment intervention in COPD should not be restricted to one single endpoint.
Physiological and Symptom Correlates of Exercise Tolerance in COPD Patients
COGO, Annaluisa;
2006
Abstract
Aim: An ongoing multicentre, randomised, placebo-controlled study evaluating the impact of tiotropium (Spiriva) on the outcomes of rehabilitation offered the opportunity to assess the correlation of exercise endurance with lung function parameters, and patient-reported breathlessness, in 220 patients with stable COPD. Methods. Baseline parameters of patients randomised as of March 2005, were analysed for correlations of lung function parameters (Forced Expiratory Volume in one second FEV1; Forced Vital Capacity, FVC), breathlessness (Baseline Dyspnea Index, BDI) with exercise performance (Six Minute Walk Distance,6MWD). Correlations among variables were evaluated with the Spearman correlation coefficient. Results. Data from 207 COPD patients (85.5% male, [meanSD] age 678 years, age median 67 years) were available. Patients showed: FVC: 2.50 0.92 L; FEV1: 1.15 0.65 L; BDI focal score: 6.54 2.40; 6MWD: 399 120 m. SaO2: 95.5 1.7 %. The relative correlations of 6MWD to lung function parameters and patient breathlessness were: (1)with FVC : R=0.317, p< 0.0001; (2)with BDI: R = 0.227, p= 0.0011, (3)with FEV1: R=0.193, p = 0.0053. Conclusions. We conclude that in COPD patients spirometric and symptom parameters are significantly correlated with exercise tolerance. The strongest correlation of 6MWD was established to FVC, while FEV1 was more weakly correlated. Studies evaluating effects of treatment intervention in COPD should not be restricted to one single endpoint.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
