The jointed efforts of several laboratories have led to the discovery of a plethora of classes of compounds with potential anti-flaviviridae activity, which will eventually display anti-HCV activity. In the panorama in which very few molecules are expected to reach the clinical trials in the next 10 years, we believe that our results could positively contribute to the development of new active substances against these life-threatening viruses.
Three- dimensional pharmacophore modeling of hindered nucleoside analogs (HNAs) as inhibitors of the hepatitic C virus NS5B polymerase
ANGUSTI, Angela;CILIBERTI, Nunzia;MANFREDINI, Stefano;
2005
Abstract
The jointed efforts of several laboratories have led to the discovery of a plethora of classes of compounds with potential anti-flaviviridae activity, which will eventually display anti-HCV activity. In the panorama in which very few molecules are expected to reach the clinical trials in the next 10 years, we believe that our results could positively contribute to the development of new active substances against these life-threatening viruses.File in questo prodotto:
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