Nonoral routes of drug administration have been exploited as alternatives to enteral and parenteral drug delivery. The success of buccal, nasal, pulmonary, and vaginal routes depends on clinical as well as on patient compliance and commercial issues. Owing to the physiology of these sites and the unique characteristics of the biological barriers involved, the transport of foreign substances requires appropriate investigation before considering the route suitable for systemic drug therapy. In this review, the different sites of drug administration are examined with reference to recently published data on their use as drug absorption portals. In vitro, in situ, or in vivo models described by several authors as tools for understanding the effect of the formulation on drug transport have been highlighted and examined for their relevance in predicting drug absorption.
Biological In Vitro Models for Absorption by Nonoral Routes
RUSSO, Paolo;COLOMBO, Gaia
2007
Abstract
Nonoral routes of drug administration have been exploited as alternatives to enteral and parenteral drug delivery. The success of buccal, nasal, pulmonary, and vaginal routes depends on clinical as well as on patient compliance and commercial issues. Owing to the physiology of these sites and the unique characteristics of the biological barriers involved, the transport of foreign substances requires appropriate investigation before considering the route suitable for systemic drug therapy. In this review, the different sites of drug administration are examined with reference to recently published data on their use as drug absorption portals. In vitro, in situ, or in vivo models described by several authors as tools for understanding the effect of the formulation on drug transport have been highlighted and examined for their relevance in predicting drug absorption.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
