The synthesis of a no. of new 6-​alkoxy-​8,​9-​(disubstituted)​purines was accomplished by the cyclization of the corresponding intermediate 5-​amino-​4-​chloro-​6-​(alkylamino)​pyrimidines promoted by alkoxides and various N,​N-​di-​Me amides, where the latter act as solvent-​reagents. By this three-​component condensation reaction we are able to introduce an alkyl group in the 8 position of the purine ring with the concomitant nucleophilic replacement of the 6-​chloro group with an alkoxy moiety.

An efficient one-pot synthesis of 6-alkoxy-8,9-dialkylpurines via reaction of 5-amino-4-chloro-6-alkylaminopyrimidines with N,N-dimethylalkaneamides and alkoxide ions

BARALDI, Pier Giovanni;ROMAGNOLI, Romeo
2002

Abstract

The synthesis of a no. of new 6-​alkoxy-​8,​9-​(disubstituted)​purines was accomplished by the cyclization of the corresponding intermediate 5-​amino-​4-​chloro-​6-​(alkylamino)​pyrimidines promoted by alkoxides and various N,​N-​di-​Me amides, where the latter act as solvent-​reagents. By this three-​component condensation reaction we are able to introduce an alkyl group in the 8 position of the purine ring with the concomitant nucleophilic replacement of the 6-​chloro group with an alkoxy moiety.
2002
Baraldi, Pier Giovanni; Broceta, Au; DE LAS INFANTAS, Mjp; Mochun, Jjd; Espinosa, A; Romagnoli, Romeo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/517052
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