The one-pot synthesis of new 9-alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazines has been achieved. Hydrazides regioselectively reacted as nucleophiles with the 3-chloro substituent of 2,3-dichloropyrido[2,3-b]pyrazine. An intramol. cyclization afforded the tricyclic nonxanthine adenosine receptor antagonists.
Regioselective one-pot synthesis of 9-alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo-[4,3-a]pyrazines. Reactivity of aliphatic and aromatic hydrazides
ROMAGNOLI, Romeo;BARALDI, Pier Giovanni;
2005
Abstract
The one-pot synthesis of new 9-alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazines has been achieved. Hydrazides regioselectively reacted as nucleophiles with the 3-chloro substituent of 2,3-dichloropyrido[2,3-b]pyrazine. An intramol. cyclization afforded the tricyclic nonxanthine adenosine receptor antagonists.File in questo prodotto:
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