It is now generally accepted that chronically extensive stimulation of the cytokine system – and of TNF in particular – is detrimental to the heart and to peripheral tissue and that such stimulation may contribute to the pathogenesis of congestive heart failure of various causes. During the past decade, basic and clinical research has provided growing evidence for the role of systemic and local inflammatory responses that, however, have so far failed to translate into new treatments for patients. The present paper represents an attempt to critically review the general concepts that lie behind the dichotomy existing between an impressive bulk of biologic research showing the role of TNF as a pathogen in congestive heart failure and the difficulties in translating this evidence into patients’ treatment.

TNF alpha in patients with congestive heart failure

CECONI, Claudio;FERRARI, Roberto
2004

Abstract

It is now generally accepted that chronically extensive stimulation of the cytokine system – and of TNF in particular – is detrimental to the heart and to peripheral tissue and that such stimulation may contribute to the pathogenesis of congestive heart failure of various causes. During the past decade, basic and clinical research has provided growing evidence for the role of systemic and local inflammatory responses that, however, have so far failed to translate into new treatments for patients. The present paper represents an attempt to critically review the general concepts that lie behind the dichotomy existing between an impressive bulk of biologic research showing the role of TNF as a pathogen in congestive heart failure and the difficulties in translating this evidence into patients’ treatment.
2004
Ceconi, Claudio; Boraso, A; Mele, D; Guardigli, R; Ferrari, Roberto
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/516417
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 5
social impact