NK1 receptor-mediated inflammatory response was provoked by iv administration of SP or NK1 selective agonist in the rat urinary bladder. This latter effct was unmodified by a dual inhibitor of arachidonate cyclo-oxygenase and lipoxygenase. Otherwise, the effects of SP on plasma exudation occur through NK1 receptors and the release of cyclo-oxygenase metabolites of arachidonic acid, largely deriving form the interaction of the neuropeptide with mast cells.

Microvascular leakage induced by substance P in rat urinary bladder: involvement of cyclo‐oxygenase metabolites of arachidonic acid

ABELLI, Luigi;
1992

Abstract

NK1 receptor-mediated inflammatory response was provoked by iv administration of SP or NK1 selective agonist in the rat urinary bladder. This latter effct was unmodified by a dual inhibitor of arachidonate cyclo-oxygenase and lipoxygenase. Otherwise, the effects of SP on plasma exudation occur through NK1 receptors and the release of cyclo-oxygenase metabolites of arachidonic acid, largely deriving form the interaction of the neuropeptide with mast cells.
1992
Abelli, Luigi; Nappi, F; Perretti, F; Maggi, Ca; Manzini, S; Giachetti, A.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/493824
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 25
social impact