The aim of this work is to investigate the use of iodine based contrast media in mammography with two different double exposure techniques: K-Edge Subtraction Mammography and Temporal Subtraction Mammography. Both techniques have been investigated by using monochromatic beams produced at a synchrotron radiation facility and conventional beams obtained with a clinical digital mammography system. A dedicated three-component phantom containing cavities filled with different iodine concentrations has been developed and used for measurements. For each technique, information about the minimum iodine concentration which provides a significant enhancement of the detectability of the pathology by minimizing the risk due to high dose and high concentration of contrast medium has been obtained. In particular for cavities of 5 and 8 min of diameter filled with iodine solutions (0, 2, 4, 8, 16, 32 mg/ml), the minimum concentrations needed to obtain a contrast-to-noise ratio of 5 with a mean glandular dose of 2 mGy have been obtained.

Evaluation of the minimum iodine concentration for contrast enhanced subtraction mammography

BALDELLI, Paola;GAMBACCINI, Mauro;SARNELLI, Anna;TAIBI, Angelo
2007

Abstract

The aim of this work is to investigate the use of iodine based contrast media in mammography with two different double exposure techniques: K-Edge Subtraction Mammography and Temporal Subtraction Mammography. Both techniques have been investigated by using monochromatic beams produced at a synchrotron radiation facility and conventional beams obtained with a clinical digital mammography system. A dedicated three-component phantom containing cavities filled with different iodine concentrations has been developed and used for measurements. For each technique, information about the minimum iodine concentration which provides a significant enhancement of the detectability of the pathology by minimizing the risk due to high dose and high concentration of contrast medium has been obtained. In particular for cavities of 5 and 8 min of diameter filled with iodine solutions (0, 2, 4, 8, 16, 32 mg/ml), the minimum concentrations needed to obtain a contrast-to-noise ratio of 5 with a mean glandular dose of 2 mGy have been obtained.
2007
dual-energy; mammography; contrast medium
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/470670
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