In the present study, we show that retinoids inhibit Human Herpesvirus 8 (HHV-8) replication, and identify new retinoid compounds with a strong antiviral effect. The compounds specifically inhibited viral promoters, both during the early and the late phases of infection in all the cell systems tested, and resulted in up to 100-fold reduction of viral titer and release of progeny virus. The inhibition of viral replication induced by retinoids in endothelial cells, primary target of HHV-8 driven transformation in Kaposi's Sarcoma, prevented endothelial cells from developing spindle morphology and in vitro tube formation, characteristic changes associated with HHV-8 infection and transformation. Selective retinoids, particularly those with RAR agonist activity, may be good candidates for the development of antiviral drugs that may also

Retinoic Acid Analogs Inhibit Human Herpesvirus 8 Replication

CASELLI, Elisabetta;GALVAN, MONICA;SANTONI, Fabio;CASSAI, Enzo;DI LUCA, Dario
2008

Abstract

In the present study, we show that retinoids inhibit Human Herpesvirus 8 (HHV-8) replication, and identify new retinoid compounds with a strong antiviral effect. The compounds specifically inhibited viral promoters, both during the early and the late phases of infection in all the cell systems tested, and resulted in up to 100-fold reduction of viral titer and release of progeny virus. The inhibition of viral replication induced by retinoids in endothelial cells, primary target of HHV-8 driven transformation in Kaposi's Sarcoma, prevented endothelial cells from developing spindle morphology and in vitro tube formation, characteristic changes associated with HHV-8 infection and transformation. Selective retinoids, particularly those with RAR agonist activity, may be good candidates for the development of antiviral drugs that may also
2008
Caselli, Elisabetta; Galvan, Monica; Santoni, Fabio; Alvarez, S; DE LERA A., R; Ivanova, D; Gronemeyer, H; Caruso, A; Guidoboni, M; Cassai, Enzo; Dolcetti, R; DI LUCA, Dario
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/470381
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact